These drugs may 1-1,5 , the slow development of AIDS, reduce the frequency  of opportunistic infections. Apply mouth, intravenously (slow infusion),  intramuscular injection under the skin. bearer intramuscularly or under the  skin. Together with zidovudine appoint other nucleotide analogs - zaltsitabin,  didanosine, lamivudine. bearer triphosphate inhibits reverse transcriptase and  is incorporated into the nascent DNA, interrupting its growth. Similar  properties has hydroxychloroquine (Plaquenil) bearer . Inhibits the synthesis of  viral DNA and RNA. This here  manifested in the form of an attack of the disease with increasing temperature,  lake-nobom. For three-day malaria after chloroquine use within 3 days bearer  14-days primaquine treatment (destruction paraeritrotsitarnyh forms of  Plasmodium). Destruction of red blood cells leads to blockage of capillaries in  violation of the functions of various tissues. The drug is toxic, therefore  bearer is applied only locally in herpetic lesions of the eye as eye drops Insulin  Resistant Diabetes Mellitus 2 h). Distinguish three-day malaria (caused by  Plasmodium vivax, Plasmodium ovale; seizures developed after 48 h), four-day  malaria (caused by Plasmodium malariae; attacks developing-are at 72 h) and  falciparum malaria (the most severe form of malaria caused by Plasmodium  falciparum; attacks developing-are over 3672 h). The most dangerous  manifestation of malaria are bouts of disease, particularly severe in tropical  malaria. Apply with herpes simplex, herpes zoster. Assign co-jointly with  abnormal nucleotides. Application drugs is limited due to severe skin reactions  (rash, Stevens-Johnson syndrome). Zidovudine's side effects: headache, insomnia,  nausea, granule-cytopenia, anemia, liver function abnormalities, myalgia.  Zidovudine (AZT) - a synthetic analogue of the T-midina. Protease inhibitors -  indinavir, saquinavir reduce protease activity, co-torye cleave polyprotein of  the virus, forming a functionally active proteins (enzymes) and structural  proteins. Is used to treat patients infected with HIV, and preventing HIV  transmission from mother to newborn child. Erythrocytic cycle of Plasmodium,  depending on the type bearer malaria, four-cut 2-3 days end with the destruction  of here  blood cells. This leads to the development of AIDS (acquired syndrome,  immunodeficiency), which manifests itself as various bacterial, fungal and viral  infections. Nevirapine (Viramune) - non-nucleoside reverse transcriptase  inhibitor. Therefore, the treatment of AIDS, along with drugs acting HIV,  appoint other antiviral agents, as well as protivobakteri-prop antifungal,  protivoprotozoynye drugs. Distinguish interferonalfa, interferonbeta,  interferongamma. HIV infects ThCD4 + (Thelpery interacting with antigen-schimi  cells) and in connection with this greatly reduces the immune defense. Typical  OS complications of AIDS: candidiasis, kriptokokkozny meningitis herpes,  cytomegalovirus retinitis, Pneumocystis pneumonia, toxoplasmosis, LIMITED  encephalitis, salmonellosis, bacterial sepsis, Kaposi's sarcoma. Therefore, in  the treatment of malaria, especially Anemia of Chronic Disease the  funds operating in the erythrocytic forms of plasmodia and warning or terminate  bouts of the disease. Under the effect of the interferonaalfa difficult  penetration viruses into cells is activated by the synthesis of antiviral  cellular enzymes, is being assembled virions and their exit from the cell. The  course of treatment of tropical malaria, while maintaining the sensitivity of  P-falciparum to chloroquine was 3 days. 
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